Cocaine's colocalized effects on synaptic serotonin and dopamine in ventral tegmentum in a reinforcement paradigm
Identifieur interne : 001384 ( Main/Exploration ); précédent : 001383; suivant : 001385Cocaine's colocalized effects on synaptic serotonin and dopamine in ventral tegmentum in a reinforcement paradigm
Auteurs : Patricia A. Broderick [États-Unis]Source :
- Pharmacology, Biochemistry and Behavior [ 0091-3057 ] ; 1992.
English descriptors
- Teeft :
- Accumbens, Activity pattern analysis, Acute administration, Animal movements, Anova, Basal, Basal values, Behavioral, Behavioral chamber, Behavioral data, Behavioral events, Behavioral parameters, Biogenic amine effects, Biogenic amines, Brain power, Brain tissue, Broderick, Central ambulations, City university, Cocaine, Cocaine acts, Cocaine administration, Cocaine reinforcement, Cocaine study, Cocaine treatment, Confidence limits, Dopamine, Electroactive species, Electrochemical, Electrochemical signal, Extracellular, Fine movements, Fisher plsd, Fourth hour, Gating mechanism, Impulse frequency, Impulse frequency rates, Indicator microelectrode, Indicator microelectrodes, Infrared photocell beams, Innervate neurons, Locomotor activity, Medial forebrain bundle, Microelectrode, Neuron, Neuropharmacological basis, Nucleus accumbens, Oxford university press, Peak area, Peak height, Pearson product, Pharmacol, Pharmacological evidence, Physiological saline, Plateau effect, Present data, Present findings, Present studies, Psychostimulant, Psychostimulant behavior, Psychostimulant behaviors, Raphe, Raphe nuclei, Rattus norvegicus, Reinforcement, Reinforcement paradigm, Release mechanisms, Representative activity pattern plots, Respective hours, Rhesus monkey, Scheffe, Serotonin, Significant differences, Somatodendritic cell, Surgical procedure, Synaptic, Synaptic concentrations, Synaptic junctions, Synaptic serotonin, Tegmental, Temporal effects, Temporal patterns, Third hour, Ventral, Ventral tegmental area, Ventral tegmentum, Vivo, Vivo electrochemical, Vivo electrochemical signals, Vivo electrochemistry, Vivo voltammetry, Vivo voltammogram, Voltammogram.
Abstract
Abstract: The effect of subcutaneous (SC) cocaine (20 mg/kg) on synaptic concentrations of the biogenic amines, dopamine (DA), and serotonin (5-HT) in Ventral Tegmental Area, (VTA-[A10]) was studied in freely moving and behaving rats (rattus norvegicus) with in vivo voltammetry (in vivo electrochemistry). The actual detection of the biogenic amines was on-line and within a temporal resolution of seconds. Simultaneously, the psychostimulant behavior induced by cocaine was studied by infrared photocell beam detection. The results show that cocaine concurrently and significantly increased synaptic concentrations of DA (p < 0.0001) and 5-HT (p < 0.004) in VTA. Serotonin changes were accompanied by a notable oscillatory pattern. Importantly, DA and 5-HT changes in VTA were significantly and positively correlated (p < 0.01). Moreover, psychostimulant behaviors induced by cocaine were significantly increased over control values (p < 0.0001). Psychostimulant behaviors were significantly correlated with concurrently changing synaptic concentrations of DA (p < 0.01) and also with 5-HT to a lesser degree. Additionally, behavioral data indicate that cocaine may exhibit an anxiolytic effect during acute administration because agoraphobic behavior, as shown by increased central ambulatory behavior, was dramatically reduced by cocaine. Summarily, the present findings show that cocaine increased synaptic concentrations of DA in VTA, an action that is correlated with cocaine-induced psychostimulant behavior. The DA-ergic effect appears to be tonically maintained. Furthermore, new findings demonstrate a colocalized, cocaine induced 5-HT-ergic effect in VTA, which keeps pace with cocaine-induced alterations in DA-ergic neurotransmission. Thus, 5-HT may be a relay or a gating mechanism for a DA reward signalling pathway for cocaine.
Url:
DOI: 10.1016/0091-3057(92)90045-H
Affiliations:
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Broderick</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pharmacology, The City University of New York Medical School, Departments of Biology and Psychology, CUNY Graduate School, New York, NY 10031</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Pharmacology, Biochemistry and Behavior</title><title level="j" type="abbrev">PBB</title><idno type="ISSN">0091-3057</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1992">1992</date><biblScope unit="volume">42</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="889">889</biblScope><biblScope unit="page" to="898">898</biblScope></imprint><idno type="ISSN">0091-3057</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0091-3057</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Accumbens</term><term>Activity pattern analysis</term><term>Acute administration</term><term>Animal movements</term><term>Anova</term><term>Basal</term><term>Basal values</term><term>Behavioral</term><term>Behavioral chamber</term><term>Behavioral data</term><term>Behavioral events</term><term>Behavioral parameters</term><term>Biogenic amine effects</term><term>Biogenic amines</term><term>Brain power</term><term>Brain tissue</term><term>Broderick</term><term>Central ambulations</term><term>City university</term><term>Cocaine</term><term>Cocaine acts</term><term>Cocaine administration</term><term>Cocaine reinforcement</term><term>Cocaine study</term><term>Cocaine treatment</term><term>Confidence limits</term><term>Dopamine</term><term>Electroactive species</term><term>Electrochemical</term><term>Electrochemical signal</term><term>Extracellular</term><term>Fine movements</term><term>Fisher plsd</term><term>Fourth hour</term><term>Gating mechanism</term><term>Impulse frequency</term><term>Impulse frequency rates</term><term>Indicator microelectrode</term><term>Indicator microelectrodes</term><term>Infrared photocell beams</term><term>Innervate neurons</term><term>Locomotor activity</term><term>Medial forebrain bundle</term><term>Microelectrode</term><term>Neuron</term><term>Neuropharmacological basis</term><term>Nucleus accumbens</term><term>Oxford university press</term><term>Peak area</term><term>Peak height</term><term>Pearson product</term><term>Pharmacol</term><term>Pharmacological evidence</term><term>Physiological saline</term><term>Plateau effect</term><term>Present data</term><term>Present findings</term><term>Present studies</term><term>Psychostimulant</term><term>Psychostimulant behavior</term><term>Psychostimulant behaviors</term><term>Raphe</term><term>Raphe nuclei</term><term>Rattus norvegicus</term><term>Reinforcement</term><term>Reinforcement paradigm</term><term>Release mechanisms</term><term>Representative activity pattern plots</term><term>Respective hours</term><term>Rhesus monkey</term><term>Scheffe</term><term>Serotonin</term><term>Significant differences</term><term>Somatodendritic cell</term><term>Surgical procedure</term><term>Synaptic</term><term>Synaptic concentrations</term><term>Synaptic junctions</term><term>Synaptic serotonin</term><term>Tegmental</term><term>Temporal effects</term><term>Temporal patterns</term><term>Third hour</term><term>Ventral</term><term>Ventral tegmental area</term><term>Ventral tegmentum</term><term>Vivo</term><term>Vivo electrochemical</term><term>Vivo electrochemical signals</term><term>Vivo electrochemistry</term><term>Vivo voltammetry</term><term>Vivo voltammogram</term><term>Voltammogram</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The effect of subcutaneous (SC) cocaine (20 mg/kg) on synaptic concentrations of the biogenic amines, dopamine (DA), and serotonin (5-HT) in Ventral Tegmental Area, (VTA-[A10]) was studied in freely moving and behaving rats (rattus norvegicus) with in vivo voltammetry (in vivo electrochemistry). The actual detection of the biogenic amines was on-line and within a temporal resolution of seconds. Simultaneously, the psychostimulant behavior induced by cocaine was studied by infrared photocell beam detection. The results show that cocaine concurrently and significantly increased synaptic concentrations of DA (p < 0.0001) and 5-HT (p < 0.004) in VTA. Serotonin changes were accompanied by a notable oscillatory pattern. Importantly, DA and 5-HT changes in VTA were significantly and positively correlated (p < 0.01). Moreover, psychostimulant behaviors induced by cocaine were significantly increased over control values (p < 0.0001). Psychostimulant behaviors were significantly correlated with concurrently changing synaptic concentrations of DA (p < 0.01) and also with 5-HT to a lesser degree. Additionally, behavioral data indicate that cocaine may exhibit an anxiolytic effect during acute administration because agoraphobic behavior, as shown by increased central ambulatory behavior, was dramatically reduced by cocaine. Summarily, the present findings show that cocaine increased synaptic concentrations of DA in VTA, an action that is correlated with cocaine-induced psychostimulant behavior. The DA-ergic effect appears to be tonically maintained. Furthermore, new findings demonstrate a colocalized, cocaine induced 5-HT-ergic effect in VTA, which keeps pace with cocaine-induced alterations in DA-ergic neurotransmission. Thus, 5-HT may be a relay or a gating mechanism for a DA reward signalling pathway for cocaine.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Broderick, Patricia A" sort="Broderick, Patricia A" uniqKey="Broderick P" first="Patricia A." last="Broderick">Patricia A. Broderick</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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